DBCO-PEG4-GGFG-DMEA-PNU159682 is a click-reactive Drug-linker that contains a DBCO group and can undergo strain-promoted acetylene-nitride cycloaddition reaction (SPAAC) with molecules containing Azide groups. PNU159682 is a DNA topoisomerase II (Topo II) inhibitor. DBCO-PEG4-GGFG-DMEA-PNU159682 can be used in the synthesis of antibody-drug conjugates (ADC).
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