MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.
Molecular Weight:
502.348
CAS Number:
[1952236-19-9]
Formula:
C22H14Cl2FN5O2S
Target:
Syk|||Apoptosis|||EGFR|||PI3K
T206251
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