Ran-IN-1 (Compound M36) is an orally active and selective inhibitor of Ran GTPase. It binds allosterically with high specificity to the switch II pocket of GDP-bound Ran (RanGDP), stabilizing its inactive state and reducing the formation of active Ran-GTP. Ran-IN-1 induces apoptosis in epithelial ovarian cancer (EOC) cells and inhibits DNA repair pathways such as homologous recombination (HR) and non-homologous end joining (NHEJ). This compound shows potential for research in epithelial ovarian cancer, particularly in high-grade serous carcinoma.
Molecular Weight:
517.56
CAS Number:
[2301869-11-2]
Formula:
C27H26F3NO4S
Target:
GTPase|||Apoptosis
T206660
* VAT and and shipping costs not included. Errors and price changes excepted
