CHD-1 is a hypoxia-activated antitumor prodrug. It disrupts the mitochondrial morphology and membrane potential of hypoxic tumor cells, leading to excessive mitophagy and inducing apoptosis. In vitro, CHD-1 inhibits the growth of hypoxic tumor cells, while in vivo, it suppresses the growth of HeLa xenograft tumors.
Molecular Weight:
301.269
CAS Number:
[3041166-70-2]
Formula:
C16H12FNO4
Target:
Apoptosis|||Mitophagy
T206731
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