Anti-inflammatory agent 100 (Compound (+)-4S-23) is an anti-inflammatory compound. It inhibits the MAPK and NF-kappaB signaling pathways by preventing the phosphorylation of IkappaB-alpha and blocking the nuclear translocation of phosphorylated p65. Anti-inflammatory agent 100 also reduces the production of NO (IC50: 0.5 µM) and the secretion of TNF-alpha, IL-6, and IL-1beta.
Target:
NF-kappaB|||ERK|||JNK|||p38 MAPK
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