Neuroprotective agent 10 (Compound 11c) is a brain-penetrant neuroprotective compound. It effectively scavenges ABTS radicals (IC50 for scavenging: 9.20 µM), DPPH radicals (IC50 for scavenging: 7.09 µM), and superoxide anion radicals (inhibition rate: 48.4%). Additionally, it mitigates oxidative damage induced by H2O2 and neuroinflammation induced by lipopolysaccharides, demonstrating antiepileptic properties. Neuroprotective agent 10 shows promise for research in epilepsy and neuroprotection.
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