Mal-N(Me)-C6-N(Me)-PNU-159682, CAS [[2682939-57-5]] Preis auf Anfrage

Product Overview

• Article Name: Mal-N(Me)-C6-N(Me)-PNU-159682, CAS [[2682939-57-5]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T206781
• Supplier Catalog Number: T206781
• Alternative Catalog Number: TGM-T206781-10MG, TGM-T206781-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

Mal-N(Me)-C6-N(Me)-PNU-159682 (Compound 27) is an active molecular conjugate used in antibody-drug conjugates (ADCs), consisting of the ADC linker Mal-N(Me)-C6-N(Me) and the potent cytotoxin PNU-159682. This compound selectively delivers its payload to cells expressing CD46 and releases PNU-159682 through cathepsin B cleavage of the linker, inducing DNA damage and apoptosis. Mal-N(Me)-C6-N(Me)-PNU-159682 has demonstrated sustained tumor regression in patient-derived xenograft (PDX) models of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC).

Product Properties

• Molecular Weight: 948.964
• CAS Number: [2682939-57-5]
• Formula: C47H56N4O17
• Target: Apoptosis|||Drug-Linker Conjugates for ADC

Images

T206781