Autotaxin-IN-7 (45) is a pyridine-2-carboxylic acid derivative exhibiting sub-nanomolar inhibition of ATX (IC50 = 0.086 nM) and features excellent cardiac safety (hERG > 30 µM) with minimal toxicity to fibroblasts. It inhibits the TGF-beta/Smad signaling pathway, reducing alpha-smooth muscle actin (alpha-SMA) and extracellular matrix components (ECM). Autotaxin-IN-7 (45) can be used in pulmonary fibrosis research.
Target:
PDE|||TGF-beta/Smad
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