PSSI-51 is an orally active inhibitor of succinyl-CoA:3-ketoacid CoA transferase (SCOT) with selectivity for peripheral tissues. It effectively inhibits SCOT activity in peripheral tissues such as muscle and kidney, without affecting SCOT activity in brain tissue. By inhibiting SCOT, PSSI-51 reduces ketone body oxidation, thereby improving obesity-related hyperglycemia. It shows potential for research in type 2 diabetes (T2D) and in addressing obesity-related metabolic disorders.
Molecular Weight:
548.45
Formula:
C28H29Cl2F2N3O2
Target:
Others
T207137
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