MS105 is an orally active, selective protein tyrosine kinase 6 (PTK6) PROTAC degrader. It recruits the VHL E3 ligase through a VHL ligand fragment, facilitating ubiquitination and proteasomal degradation of PTK6, thereby inhibiting the proliferation and migration of breast cancer cells and inducing apoptosis (apoptosis). MS105 is a promising compound for breast cancer research.
Molecular Weight:
1072.3
CAS Number:
[2408339-39-7]
Formula:
C56H70FN13O6S
Target:
Tyrosinase|||Apoptosis|||PROTACs
T207347
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