FGT-4 is a chimeric molecule targeting folate receptor beta (FR-beta) and functions as a TLR7 agonist. It enhances the secretion of iNOS and the pro-inflammatory cytokine IL-6 associated with M1 macrophages and promotes the proliferation of cytotoxic CD8+ T cells. FGT-4 demonstrates antitumor activity in the 4T1 breast cancer mouse model and is applicable for cancer immunotherapy research.
Formula:
C50H57N11O9S2
Target:
TLR|||PROTACs|||NO Synthase
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