DN-108, a thiazolidinedione derivative, acts as an orally active peroxisome proliferator-activated receptor gamma (PPARgamma) agonist with antidiabetic properties. It improves hyperglycemia, hypertriglyceridemia, and hyperinsulinemia in diabetic mouse models. DN-108 enhances tissue glucose uptake (e.g., increases 2-deoxyglucose uptake in L6 muscle cells) and inhibits fatty acid synthase activity, making it a promising candidate for type 2 diabetes research.
Molecular Weight:
366.43
CAS Number:
[195604-21-8]
Formula:
C20H18N2O3S
Target:
PPAR
T207495
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