PI3K-IN-59 (Compound 3d) is a PI3K inhibitor with an IC50 value of 17.44 µM. It demonstrates significant antiproliferative activity, showing potent inhibition against breast cancer 4T1 cells (IC50: 3.70 µM), colon cancer CT26 cells (IC50: 1.98 µM), and human breast cancer cells (IC50: 19.72 µM). The compound operates through a dual antitumor mechanism by inhibiting PI3Kalpha enzymatic activity and inducing hydroxyl radical (OH) generation via the Fenton reaction. PI3K-IN-59 shows promising efficacy against 4T1 tumors, making it suitable for synergistic targeting studies in breast and colon cancer.
Formula:
C25H32FeN6O4
Target:
PI3K|||Reactive Oxygen Species
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