MASTL/Aurora A-IN-1, CAS [[321945-24-8]] Preis auf Anfrage

Product Overview

• Article Name: MASTL/Aurora A-IN-1, CAS [[321945-24-8]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T207603
• Supplier Catalog Number: T207603
• Alternative Catalog Number: TGM-T207603-10MG,TGM-T207603-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

MASTL/Aurora A-IN-1 (Compound MA4) is a dual inhibitor of MASTL and Aurora A kinases, with IC50 values of 0.56 µM and 0.16 µM, respectively. This compound exhibits broad-spectrum anticancer activity, demonstrating potent effects against NCI-60 cancer cell lines, including SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma) with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 µM. By inhibiting Aurora A and MASTL kinases, MASTL/Aurora A-IN-1 induces G2/M phase cell cycle arrest, thereby impeding cancer cell proliferation. This compound is applicable for cancer research, particularly in the study of tumors with mitotic dysregulation.

Product Properties

• Molecular Weight: 310.41
• CAS Number: [321945-24-8]
• Formula: C18H18N2OS
• Target: Serine Protease|||Aurora Kinase

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T207603