MS2133 is a DOT1L PROTAC degrader. It facilitates the ubiquitination and degradation of DOT1L in THP-1 and MV4-11 cells, with DC50 values of 56 nM and 25 nM, respectively, and reduces H3K79 methylation. MS2133 also inhibits the growth of MLL-r leukemia cells, demonstrating anticancer activity.
Formula:
C58H66ClF3N14O11S2
Target:
PROTACs|||Histone Methyltransferase
* VAT and and shipping costs not included. Errors and price changes excepted
