YX-02-030M is a PROTACMDM2 degrader. It inhibits the binding of MDM2 to p53 and VHL to HIF1alpha, with IC50 values of 63 nM and 1.35 µM, respectively. YX-02-030M binds to MDM2 and recruits the VHL E3 ubiquitin ligase to initiate MDM2 degradation, effectively killing p53 mutant or deficient triple-negative breast cancer (TNBC) cells.
Molecular Weight:
1267.41
CAS Number:
[3049076-98-1]
Formula:
C66H85Cl2N9O10S
Target:
PROTACs|||MDM-2/p53
T208219
* VAT and and shipping costs not included. Errors and price changes excepted