PDEdelta autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEdelta. This compound effectively reduces PDEdelta protein levels through lysosome-mediated autophagy without affecting PDEdelta mRNA expression. Additionally, PDEdelta autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.
Formula:
C41H42Br2IN7O5
Target:
PROTACs|||Autophagy|||PDE|||ATTECs
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