KRAS G13D-IN-1 (compound 41) is a selective and covalent reversible inhibitor of KRASG13D with an IC50 value of 0.41 nM, exhibiting 29-fold selectivity over wild-type KRAS. It acts as a GDP-state inhibitor and targets the SWII binding pocket of KRASG13D. KRAS G13D-IN-1 inhibits GDP binding to KRAS and modulates downstream signaling cascades.
Formula:
C43H45ClF4N8O2
Target:
Ras
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