Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 µM) and Huh7 (IC50 = 8.27 µM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.
Formula:
C27H24Br2N4O8
Target:
ATG|||p62|||Autophagy
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