P-gp inhibitor 20 (Compound H27) is a P-glycoprotein (P-gp) inhibitor characterized by low cytotoxicity. It reverses multidrug resistance (MDR) in MCF-7/ADR cells by inhibiting the efflux function of P-gp in a dose-dependent manner without affecting P-gp expression, with an IC50 value of 46.6 nM. P-gp inhibitor 20 is suitable for cancer research.
Formula:
C30H28N4O3Se
Target:
P-gp
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