MS8847 is a potent EZH2PROTAC degrader that recruits the E3 ligase von Hippel-Lindau (VHL). It degrades EZH2 efficiently through a ubiquitin-proteasome system-dependent mechanism. MS8847 effectively inhibits the growth of acute myeloid leukemia (AML) and triple-negative breast cancer (TNBC) cells.
Molecular Weight:
1239.65
CAS Number:
[3050872-59-5]
Formula:
C70H98N10O8S
Target:
PROTACs|||Histone Methyltransferase
T209133
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