II399 is a potent and selective dual-substrate inhibitor of NNMT, featuring an unconventional SAM mimic, with a Ki value of 5.9 nM. It exhibits a notable competitive inhibition pattern against NAM and can occupy both the substrate and cofactor binding pockets. II399 shows promise for research in cancer, metabolic, cardiovascular, and neurodegenerative diseases.
Molecular Weight:
481.93
CAS Number:
[2928480-72-0]
Formula:
C24H24ClN5O4
Target:
Others
T209161
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