SHP2-IN-26 (Compound 4b) is a highly selective allosteric inhibitor of SHP2, with an IC50 of 3.2 nM. It effectively inhibits the phosphorylation levels of ERK and AKT in NCI-H358 cells and demonstrates antitumor activity.
Formula:
C20H22Cl2N6OS
Target:
Phosphatase
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