Tubulin degrader 1 (Compound 5i), a derivative of BML284, is an orally active non-covalent microtubule protein degrader targeting the colchicine site. It exhibits IC50 values ranging from 0.02 to 0.05 µM across five tumor cell lines (Hela, HCT116, MCF-7, K562, and Molm-13). Tubulin degrader 1 demonstrates antiproliferative properties and effectively inhibits tumor growth.
Target:
Microtubule Associated
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