GSK-3beta/HDAC-IN-1 (Compd 4) is a pioneering non-ATP competitive inhibitor that can penetrate the blood-brain barrier, targeting glycogen synthase kinase 3beta/histone deacetylases (GSK-3beta/HDACs). It exhibits IC50 values of 0.142 µM for GSK-3beta, 0.03 µM for HDAC2, and 0.045 µM for HDAC6. GSK-3beta/HDAC-IN-1 is utilized in Alzheimers research.
Formula:
C20H15N3O4S
Target:
HDAC|||GSK-3
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