ROR1-IN-1 (Compound 19h) is an inhibitor of receptor tyrosine kinase-like orphan receptor 1 (ROR1) with a Ki of 0.10 µM. It inhibits the proliferation of cancer cell lines H1975, A549, and MDA-MB-231, with IC50 values of 0.36 µM, 1.37 µM, and 0.47 µM, respectively. In mice, ROR1-IN-1 demonstrates antitumor efficacy and exhibits favorable pharmacokinetic properties in a rat model.
Molecular Weight:
541.6
CAS Number:
[3053223-31-4]
Formula:
C33H27N5O3
Target:
ROR
T210170
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