WRN-IN-19 (Compound (S)-27) is a covalent WRN helicase inhibitor, with a pIC50 of 5.4 at 0 hours and 7.5 at 4 hours in a DNA-unwinding endpoint assay. It demonstrates synthetic lethality against MSI-H (high microsatellite instability) cancer cells.
Molecular Weight:
449.47
CAS Number:
[3058652-58-4]
Formula:
C23H26F3N3O3
Target:
DNA/RNA Synthesis
T210572
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