7,4-Dimethoxy-3-hydroxyflavone, CAS [[13198-99-7]] Preis auf Anfrage

Product Overview

• Article Name: 7,4-Dimethoxy-3-hydroxyflavone, CAS [[13198-99-7]] Preis auf Anfrage
• Biozol Catalog Number: TGM-T210631
• Supplier Catalog Number: T210631
• Alternative Catalog Number: TGM-T210631-10MG,TGM-T210631-50MG
• Manufacturer: TargetMol
• Category: Biochemikalien

Product Description

7,4-Dimethoxy-3-hydroxyflavone is an orally active PAR4 antagonist. This compound inhibits PAR4-mediated human platelet aggregation with an IC50 of 1.4 µM. It disrupts PAR4-mediated aggregation and related signaling pathways, including NF-kappaB, Ca2+/protein kinase C (PKC), Akt, ERK, and p38. In a streptozotocin (STZ)-induced diabetic mouse model, 7,4-Dimethoxy-3-hydroxyflavone inhibits vascular PAR4 expression, improves endothelial dysfunction, and reduces oxidative stress. Additionally, it prevents thrombosis in mice without affecting bleeding time.

Product Properties

• Molecular Weight: 298.29
• CAS Number: [13198-99-7]
• Formula: C17H14O5
• Target: Protease-activated Receptor|||Akt|||ERK|||p38 MAPK|||Calcium Channel|||NF-kappaB|||ROS|||PKC

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T210631