PROTACHDAC6 degrader 5 (Compound 5a) is a highly selective PROTAC that targets HDAC6. It effectively degrades HDAC6 in cells with an IC50 of 43 nM. This compound reduces HDAC6 levels through a proteasome-dependent mechanism that relies on CRBN.
Target:
PROTACs|||Ligands for E3 Ligase|||HDAC
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