PVTX-321 is an orally active estrogen receptor alpha (ERalpha) degrader. It effectively degrades ERalpha with a DC50 of 0.15 nM in MCF-7 cells and also shows inhibitory activity against ERalpha mutants with an IC50 of 59 nM. PVTX-321 holds potential for research in ER+/HER2- breast cancer.
Molecular Weight:
839
CAS Number:
[3026004-38-3]
Formula:
C51H55FN4O6
Target:
Estrogen Receptor/ERR
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