KI-TOX-A3 is a selective protein-protein interaction (PPI) inhibitor targeting the TOX protein, with an IC50 value of 0.51 µM for the TOX-KAT7 interaction. It promotes proteasomal degradation of TOX, restores KAT7-mediated H3K14 acetylation, reverses CD8+ T cell exhaustion, and inhibits proliferation of T-cell acute lymphoblastic leukemia (T-ALL) cells. KI-TOX-A3 holds potential for research in hematological malignancies, including T-ALL.
Molecular Weight:
319.31
CAS Number:
[1351116-34-1]
Formula:
C18H13N3O3
Target:
Histone Acetyltransferase
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