SOS1-IN-19 (Compound 10i) is a potent inhibitor of SOS1 (Son of Sevenless 1) with an IC50 value of 165.2 nM. It functions by blocking the GDP/GTP exchange in the KRAS signaling pathway, thereby inhibiting KRAS activation. SOS1-IN-19 shows potential for research in cancers driven by KRAS, such as non-small cell lung cancer and colorectal cancer.
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Raf
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