ELQ-453 is an inhibitor that targets the Qo site of the cytochrome bc1 complex (CytB) in the malignant Plasmodium falciparum, with an IC50 value of 0.57 µM. ELQ-453 disrupts mitochondrial function in parasites and prevents Plasmodium infection in mosquitoes, showing promise for malaria research.
Target:
Cytochromes P450|||Parasite
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