ITK-IN-6 is a potent and selective ITK inhibitor (Kd = 387 nM). It binds directly to the ITK kinase domain. This compound prevents the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus production, and IgE generation. It significantly inhibits airway inflammation and is used in asthma research.
Molecular Weight:
451.32
CAS Number:
[2616666-32-9]
Formula:
C20H16Cl2N2O4S
Target:
Tyrosine Kinases
T210969
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