RJG-2036 is a potent covalent inhibitor of human prostaglandin reductase 2 (PTGR2) with an IC50 of 100 nM. It effectively inhibits NADPH-dependent reduction reactions, significantly reducing the secretion of inflammatory factors such as TNF-alpha and the release of various pro-inflammatory eicosanoids in LPS-stimulated THP-1 macrophages. RJG-2036 shows promise for research in inflammatory diseases.
Molecular Weight:
427.48
CAS Number:
[2851993-73-0]
Formula:
C20H21N5O4S
Target:
Prostaglandin Receptor
T210973
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