P2Y1 antagonist 3 (compound 36b) is a P2Y1 antagonist capable of penetrating the blood-brain barrier (BBB), with an IC50 value of 0.50 µM. In a rat middle cerebral artery occlusion (MCAO) model, it demonstrates protective properties and exhibits neuroprotective effects against oxidative stress by upregulating Nrf2 protein levels.
Target:
P2Y Receptor
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