PROTACHDAC6 degrader 6 (Compound 12) is a selective photochemical targeting chimera (PHOTACs), a subset of PROTACs, designed to target HDAC6. Its activity is specifically activated to its cis-state upon irradiation with 390 nm light, resulting in a degradation maximum (Dmax) of approximately 50%.
Target:
PROTACs|||HDAC
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