PROTACHDAC degrader-2 is a selective PROTAC degrader of class IIb HDACs, exhibiting DC50 values of 13 nM for HDAC6 and 29 nM for HDAC10. It shows low cytotoxicity in both hematologic and solid tumor cell lines, making it useful for chemical knockdown of class IIb HDACs.
Target:
PROTACs|||HDAC
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