OXPHOS-IN-2 is an orally active inhibitor of OXPHOS, demonstrating potent inhibitory effects in PC9 cells (IC50= 12.3 nM) and Bxpc-3 cells (IC50= 250 nM in glucose medium, IC50= 17.5 nM in galactose medium). It modulates the NADH/NAD+ ratio and decreases ATP levels. OXPHOS-IN-2 induces apoptosis in tumor cells by activating reactive oxygen species (ROS) and downregulating Nrf2 levels. This compound is applicable for research in cancers such as non-small cell lung cancer and pancreatic cancer.
