ML-20, an analog of Malabaricone C, functions as both an autophagy inhibitor and a radiosensitizer. It suppresses cell proliferation and induces apoptosis (cell death). ML-20 also causes DNA double-strand breaks, loss of mitochondrial membrane potential (MMP), and lysosomal membrane permeabilization (LMP). Due to LMP, it triggers endoplasmic reticulum stress while concurrently inhibiting autophagic flux.
Target:
Apoptosis|||Autophagy
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