KBD4466 is a potent oral inhibitor of TLR7 and TLR8, with IC50 values of 0.9 nM and 2.8 nM, respectively. This compound effectively suppresses the inflammatory cytokines IL-6 and IFN-alpha. KBD4466 has shown to improve disease progression and increase survival rates in the BXSB/MpJ mouse model of systemic lupus erythematosus (SLE). It is suitable for research into autoimmune diseases.
Molecular Weight:
468.47
CAS Number:
[3023713-87-0]
Formula:
C24H23F3N6O
Target:
IFNAR|||Interleukin|||TLR
T211376
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