APH02174 is a highly selective and orally active IRAK4PROTAC degrader, with a DC50 of 4.01 nM in THP-1 cells. It blocks inflammatory signaling by inhibiting IL-6 release and is applicable for researching inflammatory diseases such as psoriasis and rheumatoid arthritis.
Molecular Weight:
870
CAS Number:
[3065494-66-5]
Formula:
C49H55N7O8
Target:
IRAK|||PROTACs|||Interleukin
T211447
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