RIPK2-IN-8, CAS [[3036254-29-9]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T211556
Supplier Catalog Number:
T211556
Alternative Catalog Number:
TGM-T211556-10MG,TGM-T211556-50MG
Manufacturer:
TargetMol
Category:
Biochemikalien
RIPK2-IN-8 is an orally active and highly selective RIPK2 inhibitor with an IC50 of 11 nM. It exhibits greater selectivity for RIPK2 over RIPK1 (IC50 > 30,000 nM) and has moderate inhibitory effects on RIPK3 (IC50 = 44.61 nM). RIPK2-IN-8 exerts anti-inflammatory effects by inhibiting the NOD2-RIPK2 signaling pathway and the expression of inflammatory cytokines IL-6 and TNFalpha. Additionally, in models of acute liver injury (ALI), RIPK2-IN-8 demonstrates both anti-inflammatory and hepatoprotective effects, making it useful for ALI research.
Molecular Weight:
453.56
CAS Number:
[3036254-29-9]
Formula:
C22H20FN5OS2
Target:
RIP kinase|||Interleukin|||NF-kappaB|||p38 MAPK
T211556
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