L14-8 is a potent inducer of ferroptosis and facilitates the degradation of PLK1 through ubiquitination, while enhancing TP53 phosphorylation and SAT1 transcription, leading to ferroptosis and the death of cancer cells. L14-8 is applicable in studies of advanced prostate cancer.
Target:
Ferroptosis|||MDM-2/p53|||PLK
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