Rivanicline (RJR-2403) hydrochloride is an agonist of neuronal nicotinic receptors. It shows high selectivity for nAChR in the rat cerebral cortex (Ki= 26 nM, EC50= 732 nM) and the alpha4beta2 subtype (Ki= 26 nM, EC50= 16 µM). This compound effectively restores learning and cognitive function impairments and is applicable in research on neurodegenerative diseases such as schizophrenia or Alzheimers disease.
Target:
AChR
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