Anticanceragent 276 (Compound 5) is a multitarget anticancer compound. It exhibits potent antitumor activity against human cancer cells, with IC50 values of 6.90 µM for HEPG2 cells and 4.48 µM for MCF7 cells. Anticanceragent 276 interacts strongly and stably with multiple targets, including topoisomerase II, VEGFR2, c-Met, EGFR, and ERalpha.