Odafosfamide ((S)-OBI-3424) is a highly selective prodrug bis-alkylating agent that is specifically activated by aldehyde-keto reductase 1C3 (AKR1C3), resulting in pronounced cytotoxicity toward tumor cell lines with elevated AKR1C3 expression, and it demonstrates significant antitumor activity in cancers such as liver cancer, non-small cell lung cancer, and leukemia, making it a targeted and mechanistically informative compound for precision oncology research.
Molecular Weight:
460.42
CAS Number:
[2097713-69-2]
Formula:
C21H25N4O6P
Target:
NADPH
T211703
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