diABZI-i functions as an orthogonal STING inhibitor, significantly suppressing cGAMP-induced IFNbeta in PBMCs with an IC50 of 49 nM. Additionally, diABZI-i activates V155M SAVI constitutive signaling in a STINGV155M THP-1 cell model, demonstrating potent agonistic activity (EC50: 17 nM). This compound is applicable in researching monogenic autoinflammatory diseases such as SAVI.
Target:
STING
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