GL64 is a selective agonist of ADGRD1 with an EC50 of 3.98 µM. It shows low selectivity for the subtypes ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4. GL64 activates ADGRD1 by mimicking the satchel sequence. It regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. Both in vivo and in vitro, GL64 effectively inhibits osteoclastogenesis and prevents bone loss. This compound is suitable for research into osteoclast-related diseases.
Molecular Weight:
509.81
CAS Number:
[488801-10-1]
Formula:
C27H19Cl3N2O2
Target:
Others|||Endogenous Metabolite
T211819
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