Nrf2-IN-4 is an Nrf2 inhibitor that induces ferroptosis by disrupting cellular iron homeostasis, promoting ferritin degradation, and ultimately triggering ferroptosis. It activates lysosomes through iron-dependent reactive oxygen species (ROS) production and lysosomal acidification. Nrf2-IN-4 demonstrates significant antitumor effects and is applicable in breast cancer research.
Molecular Weight:
426.32
CAS Number:
[2417486-06-5]
Formula:
C20H13Cl2N5S
Target:
ROS|||Nrf2|||ATG|||Ferroptosis
T211919
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